Posted: February 22, 2010

Employment Type               Full time Permanent

Hours of Work                     35 hours per week

Department                          Molecular Structure and Function

Available                               Immediately

Description of Position     The Program in Molecular Structure and Function at The Hospital for Sick Children is expanding its mandate in drug discovery, and is now accepting applications for a Faculty-level Scientist position. We are seeking an exceptional individual within the broad range of fields relating to medicinal or biological chemistry who is interested in exploiting the unique research environment provided by Canada’s largest Paediatric hospital-based research institute. We are particularly interested in qualified applicants in the following areas: medicinal or pharmaceutical chemistry; synthetic organic chemistry; in silico drug design; and biological chemistry such as the thermodynamics of protein-drug interactions related to drug discovery/development, or the small molecule modulators of biological function or disease.

Qualifications                      The successful candidate for this independent research position must have an MD or PhD degree or equivalent, and completed significant postdoctoral training. They must also have an outstanding record of research productivity. The successful candidate will also be expected to establish and maintain an externally funded research program, and to hold an academic appointment at the University of Toronto.

Salary                                    Commensurate with experience

Available to                          Internal and External Candidates

Deadline                                April 15, 2010

How to Apply:       Please e-mail your application (curriculum vitae, description of past and proposed research, and three representative publications) in PDF format to Nira Jayanetti, Program Coordinator, at: nira.jayanetti@sickkids.ca .

Candidates should also arrange to have three signed letters of recommendation sent to:

Molecular Structure & Function Search
c/o Nira Jayanetti
Hospital for Sick Children
555 University Avenue
Toronto, ON
Canada, M5G 1X8.  

Review of applications will begin April 16^th, 2010 and will continue until the position is filled.

We thank you in advance for your interest. Only those applicants selected for an interview will be contacted. In accordance with our Hospital policy, employment at Sickkids would be conditional upon providing the Hospital with satisfactory documentation of tuberculosis testing and your immunization status.

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Post-doctoral fellow position - Structure, function and mechanism of ABC transporters
University of Guelph
Guelph, ON
Posted: February 19, 2010

The Sharom laboratory (Molecular & Cellular Biology, University of Guelph, Canada) is currently seeking a recent PhD graduate for a post-doctoral position starting in 2010. Our research focusses on the structure, function and mechanism of action of two high profile members of the ABC superfamily, the mammalian P-glycoprotein multidrug transporter ABCB1, and the bacterial lipid A flippase, MsbA. We use primarily purified proteins, either in detergent solution or after functional reconstitution into lipid bilayer membranes. Our approach involves the application of biochemical approaches (enzymatic activity, protein labelling) and biophysical tools (primarily fluorescence spectroscopy, but also calorimetry and NMR spectroscopy) to study the interaction of nucleotides and drug/lipid substrates with the proteins. Our ultimate goals are to characterize the steps involved in the catalytic cycle, to elucidate how ATP hydrolysis drives transport, and to understand how membrane properties modulate protein function.

Candidates should have established ability to carry out high-level research, be strongly motivated, and capable of working independently.  Excellent English language skills, and the ability to write manuscripts for publication in internationally recognized high-quality journals, are essential. Preference will be given to candidates with experience in handling membrane proteins and lipids, or familiarity with techniques advantageous to the research goals. Fellows are expected to participate in the training and supervision of junior graduate and senior undergraduate students. Opportunities to participate in undergraduate teaching for career development will be made available if desired. The position is initially for 2 years, with the possibility of extension. The starting date is negotiable, but within the period July-December 2010 is preferred. Salary will be based on background and experience, and will typically be around CAD$40,000 plus benefits. A relocation allowance will be provided for candidates located outside North America.

The Sharom group is well-established in the field of ABC proteins, and typically comprises 2 Research Associates, 1-2 post-doctoral fellows, 2-4 graduate students and 2-3 undergraduate students. The lab is located in a new science complex with state-of-the-art equipment, including steady-state, life-time and stopped-flow fluorescence facilities, DLS particle sizer, CD spectrometer, ITC calorimeter, differential scanning calorimeter, high-field solution and solid-state NMR spectrometers, and facilities for genomics, MS, and confocal/electron microscopy. Unique opportunities also exist for collaboration with other University of Guelph researchers under the auspices of the Biophysics Interdepartmental Group. Guelph is a pleasant city (population 120,000) located close to several major population centres in southern Ontario.

Individuals interested in applying for this position should submit a curriculum vitae and publication list, a cover letter including a statement of research interests and goals, and the names of three referees to fsharom@uoguelph.ca.  Candidates may meet the PI at the ABC2010 meeting in Innsbruck (March), and the ASBMB/EB 2010 meeting in Anaheim (April).

Tenure-track appointment in Biochemistry
Mount Allison University
Sackville, NB 
Posted: February 19, 2010 

The Department of Chemistry and Biochemistry at Mount Allison University invites applications for a tenure-track appointment in Biochemistry.  Applicants should possess a Ph.D. and have a strong commitment to undergraduate teaching and research. The area of research specialization is open. Mount Allison has a graduate programme and there are strong collaborative opportunities on campus and regionally, with particular emphases on Environmental Biochemistry. We particularly seek candidates with broad expertise, and those eager to contribute strong undergraduate teaching in some combination of Metabolism, Molecular Biology, Protein Biochemistry, Membrane Biochemistry and Bioinformatics. We are well equipped for research and teaching in Biochemistry and Chemistry. New faculty are expected to launch an active research programme that integrates participation by undergraduate research students. Faculty have access to a range of internal and external funding opportunities. The appointment will be made at the rank of Assistant or Associate Professor and will commence on July 1, 2010, subject to budgetary approval. Applications should include a curriculum vitae, a statement of the candidate’s teaching interests and philosophy, and a research proposal in NSERC format. Review of applications will begin on February 26, 2010 and will continue until the position is filled. Applicants should provide the names of three or more referees. Applications are to be addressed to:

Dr. Glen Briand
Chair of the Search Committee
Department of Chemistry and Biochemistry
Mount Allison University
Sackville, NB E4L 1G8
Fax: 506-364-2313
Email: gbriand@mta.ca

http://www.mta.ca/faculty/science/chem/index.html 

Mount Allison University welcomes diversity in the workplace and encourages applications from all qualified men and women, including aboriginal peoples, persons with disabilities, and members of visible minorities. All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority. Canadians and permanent residents should indicate their citizenship status in their application.

Chair, Department of Biochemistry

The Faculty of Medicine and Dentistry at the University of Alberta invites applications for a full-time academic tenured position as Chair, Department of Biochemistry.  This position is expected to contribute to the University's reputation as a leading research-intensive post-secondary institution and thereby requires a candidate who has an international reputation as a scholar as well as outstanding and innovative research accomplishments and a doctorate.

The Chair will also be responsible for ensuring full participation of the department's 26 full-time faculty and 8 adjunct faculty in undergraduate education programs; for the continued development of a vigorous graduate research program currently comprised of 73 graduate students and 31 postdoctoral fellows; and will be expected to build on the already excellent research base within the department. 

There are opportunities to expand the faculty to take advantage of the new laboratory space within the $200 million Heritage Research Innovation Facility, completed in 2006/07.  As part of Faculty-wide resources, the department has excellent facilities for biochemical research and systems biology, from whole cell imaging to atomic resolution analysis of molecular structure and function by X-ray crystallography, NMR and electron microscopy, as well as sophisticated instrumentation for mass spectroscopy and microarray analysis. The opportunities in research are enhanced by the support of the Alberta Research Innovation Authority and by the presence in Edmonton of the National Institute of Nanotechnology. Current areas of the department's research strengths include cellular, molecular and structural biology, membrane proteins, cell signaling and lipid research; further information is available at www.biochem.ualberta.ca.

The Faculty of Medicine and Dentistry and Alberta Health Services (AHS) represent one of Canada's leading Academic Health Science Centres in one of the largest integrated health delivery regions.  With annual budgets of $200 million and $2.0 billion respectively, the two organizations are recognized nationally and internationally for their combined leadership in research, education and clinical service.  Details about the University of Alberta, Faculty of Medicine and Dentistry, Alberta Health Services and Edmonton can be found on the Faculty's website at www.med.ualberta.ca.

The anticipated commencement date for this Chair position is July 1, 2010.  Interested candidates are asked to submit an up-to-date curriculum vitae; a two-page document outlining their current research interests, educational and leadership experience; and the names and addresses of three referees before January 31, 2010.  For application instructions please visit www.careers.ualberta.ca

 

Grant MacEwan University thanks all applicants for their interest in employment, however only those selected for interviews will be contacted.

E-mail: careers@macewan.ca

Grant MacEwan University employment opportunities can be viewed by visiting our website at