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52nd Annual Meeting of the Canadian Society for Biochemistry, Molecular and Cellular Biology
Protein Folding: Principles and Diseases
June 1 - 5, 2009
White Oaks Conference Resort, 253 Taylor Road
Niagara-on-the-Lake, Ontario, L0S 1J0
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Scientific Program
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All Sessions held in Grand Events Rooms A/B
Meals are in the Sunhill Dining Room
Poster Displays are in Grand Events Room C
Coffee Breaks are in the Garden View Foyer |
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Monday June 1
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12:00 - 6:00 pm
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Registration
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2:00 - 5:00 pm
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CIHR
Training Program in Protein Folding: Trainee
Minisymposium
For minisymposium schedule, click here
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6:00 pm
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Dinner
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7:30 - 9:00 pm
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CSBMCB Young Scientist Award Lecture
Mick Bhatia (McMaster) Cellular and molecular characterization of human pluripotent stem cells
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9:00 pm
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Opening Mixer
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Tuesday June 2
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| 7:00 am
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Breakfast |
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Session 1: Protein Folding in the Cell
Chair: Gergely Lukacs (McGill)
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8:15 am
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Susan
Lindquist (Whitehead Institute) Happy Birthday Darwin!
Protein folding propels evolution
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| 8:50 |
Chris
Kaiser (MIT)
The Meaning and
Mechanisms of Redox Homeostasis in the ER |
9:25
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Alan
Davidson (U Toronto) The
important role of unstructured protein regions in bacteriophage
assembly |
10:00
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Coffee break
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10:30
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Jason Young (McGill) Functional diversity of Hsc70 co-chaperones |
| 10:50 |
Bill
Balch (Scripps) Managing
folding and traffic in human misfolding disease
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11:25
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David
Thomas (McGill) Correcting the
trafficking defect of ΔF508 CFTR
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12:00 noon
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Lunch |
1:00 - 4:00 pm
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Free time
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4:00 pm
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Poster Session I
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6:00 pm
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Dinner |
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Session
2: Theoretical & Computational Approaches to Protein
Folding
Chair: Régis Pomès (SickKIds, Toronto)
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7:30 pm
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Régis Pomès (SickKids, Toronto) Molecular mechanism of beta-sheet formation at water-nonpolar interfaces
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8:05
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Ken
A. Dill (UCSF) Modeling protein
stabilities and solubilities
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8:40
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Coffee break
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| 9:00 |
Vijay
S. Pande (Stanford) Simulating
protein folding in vitro and in vivo on experimentally relevant
timescales |
9:35
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Hue
Sun Chan (U Toronto) Cooperativity in Protein Folding: Theory
and Experiment |
10:10 - 12:00 pm
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Poster Pub |
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Wednesday June 3
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| 7:00 am |
Breakfast |
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Session 3: Mechanisms of Protein Folding and Misfolding
Chair: Charles Deber (SickKIds, Toronto)
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8:15 am
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Chris
Dobson (Cambridge) Protein
Misfolding and Disease: From the Test Tube to the
Organism
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8:50
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Charles Deber (SickKids, Toronto) Peptide approaches to membrane protein folding
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9:25
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Susan Marqusee (UC Berkeley) Manipulating the folding landscape using the optical tweezers |
| 10:00 |
Coffee break |
10:30
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Art Horwich (Yale) Chaperone action in vitro and in an ALS model |
| 11:05 |
Linda Foit (U Michigan) Optimizing protein stability in vivo offers new insights into the conflicting forces in protein evolution |
11:25
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Lewis
Kay (U Toronto) Seeing the
invisible by solution NMR spectroscopy
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12:00 noon
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Lunch |
| 1:00 - 4:00 pm |
Free Time
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4:00 pm
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Poster Session II
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6:00 pm
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Dinner |
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Session 4: Cellular Responses to Protein Misfolding
Chair: Allen Volchuk (UHN, Toronto)
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| 7:30 |
Walid
Houry (U Toronto) The role of nucleotides and amino acid
decarboxylases in the bacterial acid stress
response
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8:05
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Ron Kopito (Stanford) Prion-like properties of polyglutamine amyloids |
8:40
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Coffee break
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9:00
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Randy
Kaufman (U Michigan) Interactions between protein misfolding in the ER and
oxidative stress |
9:35
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David
Ron (Skirball Inst., NYU) Prospects for tuning the Unfolded
Protein Response |
10:10 - 12:00 pm
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Poster Pub |
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Thursday June 4
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| 7:00 am |
Breakfast |
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Session 5: Protein Dynamics and Disorder
Chair: Scott Prosser (U Toronto)
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| 8:15 am |
Peter
Wright (Scripps) Promiscuous
proteins: folding and interactions of intrinsically disordered
proteins
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8:50
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Julie
Forman-Kay (SickKids, Toronto) Disordered Protein Interactions within Highly Dynamic
Regulatory Protein Complexes |
9:25
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Lawrence
Macintosh (UBC) Rheostatic
control of gene expression: conformational
flexibility and phosphorylation-dependent
regulation of Ets transcription factor |
10:00
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Coffee break |
10:30
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Peter
Tompa (Budapest) Unusual modes of molecular recognition by
disordered proteins |
11:05
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George Harauz (U Guelph) Induced Secondary Structure and Polymorphism in Myelin Basic Protein, an Intrinsically Disordered Organizational Linker of the CNS
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11:25
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Mitsu Ikura (UHN, Toronto) STIM1-mediated store-operated calcium entry uses a protein unfolding/oligomerization-coupled mechanism?
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12:00 noon
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Lunch |
1:00 - 4:00 pm
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Featured Workshop: Prion Protein
Misfolding - Canadian Contributions to Protein Structure and Dynamics
Organized by PrioNet Canada and the Alberta Prion Research Institute
Speakers include: Avi Chakrabartty, University of Toronto; Will Guest, University of British Columbia; Michael James, University of Alberta; Nahid Jetha, University of British Columbia; Olivier Julien, University of Alberta; Nat Kav, University of Alberta; Braden Sweeting, University of Toronto; David Wishart, University of Alberta |
4:00 - 5:00 pm
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CSBMCB Annual General Meeting
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6:00 - 7:00 pm
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Mixer |
7:00 - 9:30 pm
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Banquet and Awards Presentation |
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Friday June 5
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| 7:00 am |
Breakfast |
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Session 6: Protein Misfolding in Aging
and Disease
Chair: Neil Cashman (UBC)
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| 8:15 am |
Peter
St. George-Hyslop (U of Toronto) Molecular insights into protein misfolding in Alzheimer’s
Disease and Frontotemporal Dementia |
8:50
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Cynthia
Lemere (Brigham and Women’s) Immunotherapy for Alzheimer's and Other Neurodegenerative
Diseases |
9:25
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Jeff
Kelly (Scripps) Restoring
Proteostasis to Ameliorate Disease
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10:00
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Coffee break |
10:30
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David
Westaway (U of Alberta) Attributes and Overlaps of the PrP and Shadoo
proteins |
11:05
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Jeremy Lee (U Sask) Nanopore analysis of the interaction of metal ions and antibodies with prion proteins |
11:25
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David
Vocadlo (SFU) Modulators of
intracellular glycosylation limit microtubule-associated protein tau phosphorylation in
vivo |
12:00 noon
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Lunch and Departure |
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