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Carrières dans le domaine des sciences
Updated: July 27, 2010
Postes pour étudiants gradués et chercheurs postdoctoraux
Le programme FONCER (Programme de formation orientée vers la nouveauté, la collaboration et l’expérience en recherche) du CRSNG
Posted: July 27, 2010
CDMC est un programme de formation innovateur et interdisciplinaire dans le domaine de la Dynamique cellulaire des complexes macromoléculaires («Cellular dynamics of macromolecular complexes - CDMC»). Financé depuis 2010 par le programme FONCER (Programme de formation orientée vers la nouveauté, la collaboration et l’expérience en recherche) du CRSNG, le programme CDMC entraine les étudiants et les stagiaires postdoctoraux pour la recherche au sein des laboratoires de 28 chercheurs reconnus mondialement et ce, dans 8 institutions à travers le Canada et les États-Unis. Les mentors du CDMC utilisent les concepts et les techniques de biochimie, bio-informatique, biologie cellulaire, imagerie, protéomique et biologie structurale les plus modernes afin de comprendre les interactions moléculaires entre les macromolécules qui sont à l’origine des processus de la vie.
CDMC est présentement en recrutement d¹étudiants gradués et postdoctoraux pour un début en mai 2011 (date limite pour soumission des candidatures est le 1er janvier 2011).
Pour toute demande de renseignements concernant le programme, la soumission de candidatures et les laboratoires hôte veuillez consulter le site web du programme: http://www.cdmc-create.ca/index_FR.html
Christian Baron
Principal investigator
Department of Biochemistry
Université de Montréal
Email: Christian.baron@umontreal.ca
Postdoctoral Position
Queen's University
Kingston, Ontario, Canada
Posted: June 16, 2010
A postdoctoral position is available in Prof. Susan P.C. Cole’s laboratory in the Division of Cancer Biology & Genetics in the Cancer Research Institute at Queen’s University (Kingston, Ontario, Canada) [http://qcri.queensu.ca]
Research in the COLE laboratory focuses on the clinically important human MRP-related transporters that mediate ATP-dependent efflux of drugs and other organic anions, including several important signalling molecules. Ongoing projects include investigations of
(i) the complex role of glutathione as a MRP1 substrate and modulator [Rothnie et al. 2008 Mol Pharmacol 74:1630];
(ii) structure/function relationships of MRP1 and ABCC4/MRP4 [Conseil et al. 2009 Mol Pharmacol 75:397; Maeno et al. 2009 Drug Metab Disp 37:1411]; and
(iii) protein binding partners of MRP1 and ABCC4 [Hoque & Cole 2008 Cancer Res 68:4802].
Utilizing our access to state-of-the-art equipment, we employ a wide range of molecular, biochemical and cellular techniques, including mass spectrometry, site-directed mutagenesis, vesicular transport methods, confocal microscopy, etc.
Established in 1841, Queen's is one of Canada's leading universities with an international reputation for scholarship, research, and spirit. The University is located in Kingston in southeastern Ontario on the shores of Lake Ontario. Queen’s is the quintessential university community big enough to provide all the conveniences and advantages of a larger centre, but small enough for a high quality of life. Kingston is Canada's 3rd best "place to live" in Canada according to a 2009 Canadian Business publication survey.
The position is available immediately for an initial period of 1 year with the possibility of renewal for up to 3 years. The stipend will follow CIHR guidelines and broad family health care benefits as proscribed by Queen’s. The ideal candidate will be highly motivated, preferably have a recent (max 3 years) PhD and documented experience in protein biochemistry and molecular biology. Some background in mass spectrometry, cell biology and pharmacology would be an asset. Interested candidates with strong English language communication skills should submit a cover letter with a brief description of research interests and expertise, a full CV, and 2-3 references (with contact info) (preferably as PDF document) to Dr. Cole spc.cole@queensu.ca
Assistant Professor, Tenure Track
The University of British Columbia
Department of Biochemistry and Molecular Biology
Posted: April 30, 2010
The Department of Biochemistry and Molecular Biology at the University of British Columbia is seeking an outstanding new investigator for a full time tenure track faculty position, at the rank of Assistant Professor. Candidates must have a Ph.D. degree, a minimum of 2 years postdoctoral research experience, and a record of accomplishment that demonstrates their potential as an independent researcher and teacher. Candidates with research and teaching interests in any area of contemporary Biochemistry or Molecular Biology are encouraged to apply. All members of the Department maintain active, well-funded research programs that encompass many areas of modern biochemistry, molecular and structural biology. Successful candidates should complement and extend the Department's expertise in research and education. Applicants should send their curriculum vitae, a record of teaching effectiveness, 3-4 relevant reprints and a brief (2-3 page) outline of their proposed research program to:
Irene Ho, Secretary to the Department Head
Department of Biochemistry and Molecular Biology
Faculty of Medicine
The University of British Columbia
2350 Health Sciences Mall
Vancouver, BC V6T 1Z3 Canada
Email: biochsec@interchange.ubc.ca
Website: http://www.biochem.ubc.ca
Applicants should also arrange for 3 letters of reference to be sent to the above address. The deadline for applications is May 31, 2010. The anticipated start date is July 1, 2010 and is negotiable. Salary will be commensurate with qualifications and experience. UBC hires on the basis of merit and is committed to employment equity. All qualified persons are encouraged to apply. UBC is strongly committed to diversity within its community and especially welcomes applications from visible minority group members, women, Aboriginal persons, persons with disabilities, persons of any sexual orientation or gender identity, and others who may contribute to the further diversification of ideas. However, Canadian and permanent residents of Canada will be given priority.
Post-Doctoral position
Membrane biology/proteomics/structural biology
UBC, Vancouver, BC.
Posted: April 30, 2010
A post-doctoral position is available starting Summer 2010 in the Duong Laboratory - Life Science Institute - Department of Biochemistry and Molecular Biology at the University of Bristish Columbia. The successful applicant will be academically inclined towards career advancement. The research goals are to develop and apply Nanodisc technology to understand membrane transporters and protein-protein interactions that take place in the prokaryotic and eukaryotic cell membranes. The Nanodisc is a small lipid bilayer that incorporate membrane proteins into 10nm-wide soluble particles, for the application of a wide variety of methodologies such as SPR, ITC, MALS, X-linking, LC-MS/MS, NMR and fluorescence spectroscopy.
Preferences will be given to candidates with experience in the field of membrane biology or experience in biophysical/proteomic techniques advantageous to the project. Salary is commensurate with qualifications and experience according to UBC guidelines. The lab is located in a Life Science Institute http://www.lsi.ubc.ca/, a multi-disciplinary environment with state-of-the-art equipment. Applicants should send their curriculum vitae, names and full contact information for three references, and a cover letter to Dr. Franck Duong at FDuong@interchange.ubc.ca
Structural Biology/Crystallography
Tenure Track Position
University of Waterloo
Posted: April 22, 2010
Applications are being accepted for a tenure track position at the Assistant or Associate Professor level in the Department of Biology, Faculty of Science, University of Waterloo. Applicants should have a PhD and postdoctoral experience with a research record in Macromolecular X-ray Crystallography. Duties of the position include establishment of an independent research program, teaching and supervision at the undergraduate and graduate levels, and participation in the running of the Department and University. The University has instrumentation for macromolecular crystallography, including a Rigaku Micromax/R-Axis 4++ diffractometer system.
Inquiries and applications, consisting of a full curriculum vitae with publication record, statement of research interest and teaching experience, and names of three references and their contact information, should be sent electronically to the attention:
Dr. David R. Rose, Chair
Department of Biology
University of Waterloo
(Via email to Mrs. Gini Kennings, Chair's Secretary: givan@uwaterloo.ca)
The closing date for applications will be September 1, 2010, with a starting date on or after January 1, 2011.
All qualified candidates are encouraged to apply; however Canadian citizens and Permanent residents will be given priority. The University of Waterloo encourages applications from all qualified individuals, including women, members of visible minorities, native peoples, and persons with disabilities.
Poste de Professeur adjoint
Département d’anatomie et de biologie cellulaire
Faculté de Médecine et des sciences de la santé
Université de Sherbrooke, Canada
Posted: April 22, 2010
Le département d'anatomie et de biologie cellulaire de la Faculté de médecine et des sciences de la santé de l'Université de Sherbrooke sollicite des candidatures pour pourvoir à un poste de professeur adjoint pouvant mener à la titularisation (tenure track position).
Fonctions
Les candidats recherchés mènent un programme de recherche innovateur sur la biologie des cellules épithéliales, complémentaire aux expertises que possèdent les différents professeurs du département. Le candidat retenu devra établir un vigoureux programme de recherche indépendant en biologie épithéliale portant sur le développement et le maintien de l’homéostasie de la muqueuse gastro-intestinale. Le programme de recherche sera intégré aux activités de recherche de l'équipe sur l'épithélium digestif financée par les Instituts de recherche en santé du Canada (IRSC).
Exigences requises
Les candidats doivent être titulaires d'un diplôme de Ph D. ou d’un diplôme de MD/Ph.D. et avoir complété un stage postdoctoral couronné de succès dans le domaine des sciences biomédicales, leur permettant d’obtenir une bourse salariale et le financement de leur programme de recherche par un organisme externe. Ce poste de professeur adjoint implique la supervision d'étudiants de deuxième et troisième cycle en biologie cellulaire ainsi qu’une tâche d’enseignement, débutant quelques années après le recrutement, dans les différents programmes de premier cycle ainsi qu’aux cycles supérieurs. La connaissance de la langue française est essentielle.
Conditions de travail
Les conditions de travail sont régies par les conventions collectives en vigueur. L’attribution de ce poste inclut une subvention à l'établissement concurrentiel, un espace de laboratoire, l'accès à un équipement et des installations scientifiques de pointe et un environnement de recherche stimulant au sein d’un axe majeur de recherche portant sur les physiopathologies gastro-intestinales humaines. De plus amples informations sont disponibles à l’adresse suivante: http://www.usherbrooke.ca/anatbiocell/affichage_postes/page_accueil.htm
Réception des candidatures
Prière de faire parvenir votre curriculum vitae, une brève description (2 pages) de vos activités et intérêts de recherche, une copie de vos trois publications les plus significatives, ainsi que les coordonnées de trois répondants à l’attention de la Pr Nathalie Rivard: ABC.recrutement@USherbrooke.ca.
Scientist – Faculty position
Hospital for Sick Children
Program in Molecular Structure and Function
Toronto, ON
Posted: February 22, 2010
Employment Type Full time Permanent
Hours of Work 35 hours per week
Department Molecular Structure and Function
Available Immediately
Description of Position The Program in Molecular Structure and Function at The Hospital for Sick Children is expanding its mandate in drug discovery, and is now accepting applications for a Faculty-level Scientist position. We are seeking an exceptional individual within the broad range of fields relating to medicinal or biological chemistry who is interested in exploiting the unique research environment provided by Canada’s largest Paediatric hospital-based research institute. We are particularly interested in qualified applicants in the following areas: medicinal or pharmaceutical chemistry; synthetic organic chemistry; in silico drug design; and biological chemistry such as the thermodynamics of protein-drug interactions related to drug discovery/development, or the small molecule modulators of biological function or disease.
Qualifications The successful candidate for this independent research position must have an MD or PhD degree or equivalent, and completed significant postdoctoral training. They must also have an outstanding record of research productivity. The successful candidate will also be expected to establish and maintain an externally funded research program, and to hold an academic appointment at the University of Toronto.
Salary Commensurate with experience
Available to Internal and External Candidates
Deadline April 15, 2010
How to Apply: Please e-mail your application (curriculum vitae, description of past and proposed research, and three representative publications) in PDF format to Nira Jayanetti, Program Coordinator, at: nira.jayanetti@sickkids.ca .
Candidates should also arrange to have three signed letters of recommendation sent to:
Molecular Structure & Function Search
c/o Nira Jayanetti
Hospital for Sick Children
555 University Avenue
Toronto, ON
Canada, M5G 1X8.
Review of applications will begin April 16th, 2010 and will continue until the position is filled.
We thank you in advance for your interest. Only those applicants selected for an interview will be contacted. In accordance with our Hospital policy, employment at Sickkids would be conditional upon providing the Hospital with satisfactory documentation of tuberculosis testing and your immunization status.
Post-doctoral fellow position - Structure, function and mechanism of ABC transporters
University of Guelph
Guelph, ON
Posted: February 19, 2010
The Sharom laboratory (Molecular & Cellular Biology, University of Guelph, Canada) is currently seeking a recent PhD graduate for a post-doctoral position starting in 2010. Our research focusses on the structure, function and mechanism of action of two high profile members of the ABC superfamily, the mammalian P-glycoprotein multidrug transporter ABCB1, and the bacterial lipid A flippase, MsbA. We use primarily purified proteins, either in detergent solution or after functional reconstitution into lipid bilayer membranes. Our approach involves the application of biochemical approaches (enzymatic activity, protein labelling) and biophysical tools (primarily fluorescence spectroscopy, but also calorimetry and NMR spectroscopy) to study the interaction of nucleotides and drug/lipid substrates with the proteins. Our ultimate goals are to characterize the steps involved in the catalytic cycle, to elucidate how ATP hydrolysis drives transport, and to understand how membrane properties modulate protein function.
Candidates should have established ability to carry out high-level research, be strongly motivated, and capable of working independently. Excellent English language skills, and the ability to write manuscripts for publication in internationally recognized high-quality journals, are essential. Preference will be given to candidates with experience in handling membrane proteins and lipids, or familiarity with techniques advantageous to the research goals. Fellows are expected to participate in the training and supervision of junior graduate and senior undergraduate students. Opportunities to participate in undergraduate teaching for career development will be made available if desired. The position is initially for 2 years, with the possibility of extension. The starting date is negotiable, but within the period July-December 2010 is preferred. Salary will be based on background and experience, and will typically be around CAD$40,000 plus benefits. A relocation allowance will be provided for candidates located outside North America.
The Sharom group is well-established in the field of ABC proteins, and typically comprises 2 Research Associates, 1-2 post-doctoral fellows, 2-4 graduate students and 2-3 undergraduate students. The lab is located in a new science complex with state-of-the-art equipment, including steady-state, life-time and stopped-flow fluorescence facilities, DLS particle sizer, CD spectrometer, ITC calorimeter, differential scanning calorimeter, high-field solution and solid-state NMR spectrometers, and facilities for genomics, MS, and confocal/electron microscopy. Unique opportunities also exist for collaboration with other University of Guelph researchers under the auspices of the Biophysics Interdepartmental Group. Guelph is a pleasant city (population 120,000) located close to several major population centres in southern Ontario.
Individuals interested in applying for this position should submit a curriculum vitae and publication list, a cover letter including a statement of research interests and goals, and the names of three referees to fsharom@uoguelph.ca. Candidates may meet the PI at the ABC2010 meeting in Innsbruck (March), and the ASBMB/EB 2010 meeting in Anaheim (April).
Tenure-track appointment in Biochemistry
Mount Allison University
Sackville, NB
Posted: February 19, 2010
The Department of Chemistry and Biochemistry at Mount Allison University invites applications for a tenure-track appointment in Biochemistry. Applicants should possess a Ph.D. and have a strong commitment to undergraduate teaching and research. The area of research specialization is open. Mount Allison has a graduate programme and there are strong collaborative opportunities on campus and regionally, with particular emphases on Environmental Biochemistry. We particularly seek candidates with broad expertise, and those eager to contribute strong undergraduate teaching in some combination of Metabolism, Molecular Biology, Protein Biochemistry, Membrane Biochemistry and Bioinformatics. We are well equipped for research and teaching in Biochemistry and Chemistry. New faculty are expected to launch an active research programme that integrates participation by undergraduate research students. Faculty have access to a range of internal and external funding opportunities. The appointment will be made at the rank of Assistant or Associate Professor and will commence on July 1, 2010, subject to budgetary approval. Applications should include a curriculum vitae, a statement of the candidate’s teaching interests and philosophy, and a research proposal in NSERC format. Review of applications will begin on February 26, 2010 and will continue until the position is filled. Applicants should provide the names of three or more referees. Applications are to be addressed to:
Dr. Glen Briand
Chair of the Search Committee
Department of Chemistry and Biochemistry
Mount Allison University
Sackville, NB E4L 1G8
Fax: 506-364-2313
Email: gbriand@mta.ca http://www.mta.ca/faculty/science/chem/index.html
Mount Allison University welcomes diversity in the workplace and encourages applications from all qualified men and women, including aboriginal peoples, persons with disabilities, and members of visible minorities. All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority. Canadians and permanent residents should indicate their citizenship status in their application.
Chair, Department of Biochemistry
The Faculty of Medicine and Dentistry at the University of Alberta invites applications for a full-time academic tenured position as Chair, Department of Biochemistry. This position is expected to contribute to the University's reputation as a leading research-intensive post-secondary institution and thereby requires a candidate who has an international reputation as a scholar as well as outstanding and innovative research accomplishments and a doctorate.
The Chair will also be responsible for ensuring full participation of the department's 26 full-time faculty and 8 adjunct faculty in undergraduate education programs; for the continued development of a vigorous graduate research program currently comprised of 73 graduate students and 31 postdoctoral fellows; and will be expected to build on the already excellent research base within the department.
There are opportunities to expand the faculty to take advantage of the new laboratory space within the $200 million Heritage Research Innovation Facility, completed in 2006/07. As part of Faculty-wide resources, the department has excellent facilities for biochemical research and systems biology, from whole cell imaging to atomic resolution analysis of molecular structure and function by X-ray crystallography, NMR and electron microscopy, as well as sophisticated instrumentation for mass spectroscopy and microarray analysis. The opportunities in research are enhanced by the support of the Alberta Research Innovation Authority and by the presence in Edmonton of the National Institute of Nanotechnology. Current areas of the department's research strengths include cellular, molecular and structural biology, membrane proteins, cell signaling and lipid research; further information is available at www.biochem.ualberta.ca.
The Faculty of Medicine and Dentistry and Alberta Health Services (AHS) represent one of Canada's leading Academic Health Science Centres in one of the largest integrated health delivery regions. With annual budgets of $200 million and $2.0 billion respectively, the two organizations are recognized nationally and internationally for their combined leadership in research, education and clinical service. Details about the University of Alberta, Faculty of Medicine and Dentistry, Alberta Health Services and Edmonton can be found on the Faculty's website at www.med.ualberta.ca.
The anticipated commencement date for this Chair position is July 1, 2010. Interested candidates are asked to submit an up-to-date curriculum vitae; a two-page document outlining their current research interests, educational and leadership experience; and the names and addresses of three referees before January 31, 2010. For application instructions please visit www.careers.ualberta.ca
Full-Time Continuing Instructor – Biological Sciences
The Department of Biological Sciences in the Faculty of Arts and Science at Grant MacEwan University invites applications for a full-time continuing faculty position, commencing July 1, 2010. This position will contribute to the growth and success of MacEwan’s four-year Bachelor of Science degree. The candidate must have a PhD (or solid indication of imminent completion) in Biochemistry or related discipline. Applicants from all areas of Biochemistry are welcome, but particular attention will be given to those with a background in molecular and cellular aspects of Biochemistry. The candidate must demonstrate excellence, or clear promise of excellence, in teaching. A commitment to research and to the supervision of undergraduate research projects is expected. Applicants should have fluent written and oral communication skills in English. All qualified candidates are encouraged to apply; however, in accordance with Canadian immigration requirements, Canadian citizens and permanent residents will be given priority. If suitable Canadian citizens or permanent residents cannot be found, other individuals will be considered.
Applicants should submit a covering letter complete with curriculum vitae, a statement regarding teaching philosophy and interests, recent teaching evaluations, a statement of research interests and graduate transcripts. Candidates should also arrange for three letters of reference to be sent under separate cover.
Salary Range: commensurate with education and experience
Closing Date: January 8, 2010.
Quote Competition No: 09.11.266
For further information, contact the department chair, Dr. David McFadyen, at
mcfadyend@macewan.ca
Grant MacEwan University thanks all applicants for their interest in employment, however only those selected for interviews will be contacted.
Apply to:
Human Resources Department
Grant MacEwan University
City Centre Campus
7-105, 10700 104 Ave
Edmonton AB T5J 4S2
FAX: (780) 497-5430
PHONE: (780) 497-5434 (780) 497-5434
E-mail: careers@macewan.ca
Grant MacEwan University employment opportunities can be viewed by visiting our website at
Post-Doctoral Fellowship Opportunity
Protein Chaperones and Protein Translocases
Posted: December 2009
My lab has an opening for recent PhD graduates or fellows with less than 2 years PDF experience for postdoctoral positions starting early 2010. The research focuses on the system specific chaperones in bacteria that are responsible for the maturation of various membrane associated redox enzymes that utilize the Twin arginine translocation (Tat) system. This system moves folded proteins across the cell membrane.
Projects centre on DmsD, the system specific chaperone for DMSO reductase, as well as related chaperones. The substrate DmsABC goes through a complicated pathway to reach maturation and cofactor insertion. The chaperone is thought to escort the enzyme substrate through the steps of maturation. During this pathway the complex interacts with other chaperones and cofactor biosynthetic pathways as well as the Tat translocase itself. We are interested in the complete interactome of this chaperone and its substrates protein complex DmsAB. We utilize biophysical approaches (Fluorescence, calorimetry, BiaCore, etc) with molecular microbiology methods (two hybrid approaches, mutagenesis) with protein chemistry (Protein purification, cross-linking, molecular probes) to study the molecular mechanism of interaction between the chaperones and their substrates and accessory protein complexes. Many specific projects exist within this context.
Candidates should have a strong CV with evidence of research and writing ability of publications in internationally recognized quality journals. Suitable candidates will be sent further information on specific projects. It would be wise, however, for candidates to explore the labs interest and progress in the field (http://people.ucalgary.ca/~turnerr) to describe how their background or interests are key to the project. Preferences will be given to candidates with experience in the field, or experience in techniques advantageous to the project such as in vitro transcription – translation, protein cross-linking, Co-IP, and other protein-protein interaction methods. A strong background in protein chemistry or protein physical chemistry is desirable. However, a molecular microbiologist with knowledge of proteins could carry some projects out well. Fellows in my group are expected to contribute to the training and supervision of junior researchers (undergraduates and junior graduate students). Opportunities for contributing to undergraduate course lectures will be made available if interested to facilitate experience for career. Salaries will be based on experience, granting council (CIHR) and university guidelines. Information on University of Calgary and helpful resources to PDF’s at the university can be found at www.ucalgary.ca/postdoc.
The Turner group is a protein biochemistry and microbial physiology lab with interests in bacterial systems. The group is well established with 1-3 PDF’s, 2-5 graduate students, and 2-3 undergrads at any given time. To express your interest in this position send CV and cover letter of project interest to:
Professor Raymond J. Turner, PhD
Dept. of Biological Sciences,
156 Biological Sciences Building,
University of Calgary, 2500 University Dr. N.W.
Calgary, Alberta, Canada, T2N 1N4
Tel: 403-220-4308 403-220-4308 Fax:403-289-9311
E-mail:turnerr@ucalgary.ca
http://homepages.ucalgary.ca/~turnerr
PhD Graduate Research Opportunity
Membrane Protein Biochemistry
Posted: December 2009
PhD student required to work on ligand binding and protein folding of the integral membrane transporters of the Small multidrug resistance family of proteins in bacteria.
Biochemical and Biophysical characterization of the small multidrug resistance proteins SugE and EmrE from E. coli is under investigation. The study of the ligand binding, folding and multimeric states of this protein in various membrane memetic environments is under investigation. The folding and assembly is to be studied using biophysical methods of fluorescence, Infra-red spectroscopy, circular dichroism, size-exclusion HPLC, calorimetry and stop-flow methods, as well as in vivo two hybrid approaches and protein chemistry. We are interested in the drug-ligand binding to SugE and EmrE. The project is also studying the folding and multimer assembly in vitro and in vivo. Projects are available to examine amino acid residues involved in ligand binding and/or folding.
Individuals interested in protein folding of integral membrane proteins both in vivo and in vitro and/or an interest in biophysical methods applied to proteins and ligand binding would find this project attractive. This research is supported by NSERC.
Positions are available to start January, May, or Sept 2010. The Department of Biological Sciences in the faculty of Science requires a minimum of 3.2/4.0 gpa for consideration into graduate program. Successful candidates should have a M.Sc. degree in a relevant area or a B.Sc gpa of >3.6/4.0. Students will participate as teaching assistants and/or compete for scholarship support to supplement their stipend. Students are expected to participate in training and working with others by supervising junior students. For further information on the department’s graduate student policies see www.bio.ucalgary.ca/graduate/index.html.
The Turner group is a protein biochemistry and microbial physiology lab with interests only in bacterial systems. The group is well established with 1-3 PDF’s, 2-5 graduate students, and 2-3 undergrads at any given time. To express your interest in this position contact:
Professor Raymond J. Turner, PhD
Dept. of Biological Sciences,
156 Biological Sciences Building,
University of Calgary, 2500 University Dr. N.W.
Calgary, Alberta, Canada, T2N 1N4
Tel: 403-220-4308 403-220-4308 Fax:403-289-9311
E-mail:turnerr@ucalgary.ca
Web Page: http://homepages.ucalgary.ca/~turnerr/
PhD Graduate Research Opportunity
Protein Chaperones and Protein Translocases
Posted: December 2009
My lab has openings for graduate student positions starting early 2010. The research focuses on the system specific chaperones in bacteria that are responsible for the maturation of various membrane associated redox enzymes that utilize the Twin arginine translocation (Tat) system. This system moves folded proteins across the cell membrane.
Projects centre on DmsD, the system specific chaperone for DMSO reductase, as well as related chaperones. The substrate DmsABC goes through a complicated pathway to reach maturation and cofactor insertion. The chaperone is thought to escort the enzyme substrate through the steps of maturation. During this pathway the complex interacts with other chaperones and cofactor biosynthetic pathways as well as the Tat translocase itself. We are interested in the complete interactome of this chaperone and its substrates protein complex DmsAB. We utilize biophysical approaches (Fluorescence, calorimetry, BiaCore, etc) with molecular microbiology methods (two hybrid approaches, mutagenesis) with protein chemistry (Protein purification, cross-linking, molecular probes) to study the molecular mechanism of interaction between the chaperones and their substrates and accessory protein complexes. Many specific projects exist within this context.
Positions are available to start January, May or Sept 2010. The Department of Biological Sciences, faculty of Science requires a minimum of 3.2/4.0 gpa for consideration for graduate program. Successful candidates should have a M.Sc. degree in a relevant area or a gpa of >3.6/4.0. Students will participate as Teaching assistants and/or compete for scholarship support to supplement their stipend. Students are expected to participate in training and working with others by supervising junior students. For further information on the department’s graduate student policies see www.bio.ucalgary.ca/graduate/index.html.
The Turner group is a protein biochemistry and microbial physiology lab with interests only in bacterial systems. The group is well established with 1-3 PDF’s, 2-5 graduate students, and 2-3 undergrads at any given time. To express your interest in this position contact:
Professor Raymond J. Turner, PhD
Dept. of Biological Sciences,
156 Biological Sciences Building,
University of Calgary, 2500 University Dr. N.W.
Calgary, Alberta, Canada, T2N 1N4
Tel: 403-220-4308 403-220-4308 Fax:403-289-9311
E-mail:turnerr@ucalgary.ca
http://homepages.ucalgary.ca/~turnerr
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